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ISO17205 certified |
| Pre-natal DNA test: | |||
| DNA prenatal testing – DNA paternity testing during pregnancy can now accurately determine paternity before the baby is born. It is usually performed from the 9th to 25th week of pregnancy with an accuracy of 99.9% either by invasive or non-invasive. Prenatal DNA test (INVASIVE) 21,800 This type of test is done using amniotic fluid or CVS sample, usually is performed by an OB. These method results to an accuracy level of 99.9%. Although, there is risk involved, it is always advisable that you take it up with your physician – prior to engaging in PRENATAL DNA TEST.
This type test is done using blood collection from the mother during pregnancy and swab from the alleged father. These method results to an accuracy level of 99.9% and having no risks involved mat not require the attention and guidance of your physician. DNA testing can be done as early as 9 weeks gestation. If testing is ordered earlier than 9 weeks there is a chance that there will not be enough fetal DNA in the maternal plasma – in this instance DDC will request a redraw and will not issue a report. There is no cost to redraw if the first blood draw was done at 9 weeks of pregnancy or later. DDC Philippines will require a doctor’s note to prove this. A blood draw from the mother and from all alleged fathers, and completed consent forms are required for testing to be done. The test is > 99.9% accurate. This does not mean, however, that we tested 10,000 cases and produced 1 wrong answer. In fact, the test has never produced an incorrect answer to date. What it means is in order to determine paternity, the probability must be >99.9% that the alleged father contains the genetic markers required of the biological father. Results will be ready within 2 weeks from the time we collect your blood samples. Q. Why is DDCʼs testing available at 9 weeks when other paternity tests require at least 13 weeks gestation? A. The challenge is that there is so much less fetal DNA in motherʼs blood at 9 weeks vs. 13 weeks, which makes it much harder to read. To solve this problem, Natera leverages their proprietary bionformatics technology (Parental Q. Is there any published literature about your testing? A. In early October Natera published an abstract at the 2011 International Symposium on Human Identification (ISHI) titled “Non-invasive prenatal paternity testing using fetal cell free DNA from maternal blood.” Q. I have heard of other companies (like DNAPlus) that use technology analyzing whole fetal cells in paternity testing– why does you use cell free fetal DNA? A. Whole fetal cells can persist in a mother’s blood stream for decades after a pregnancy. If the patient in question has ever been pregnant there is a risk that using a technology analyzing whole fetal cells will give a misdiagnosis due because of this. Our technology uses cell free fetal DNA which is cleared from a mother’s blood stream within hours after a pregnancy, whether the termination point was delivery or miscarriage. Q. I have also heard of a few companies that use STR (short tandem repeat) technology – why do you use SNP (single nucelotide polymorphisms) and how does it compare? A. STR based tests measure areas of the genome where the number of copies of genetic code vary from person to person. When used on long strains of DNA, STR can be effective. Due to the highly fragmented nature of cell free fetal DNA (most of this DNA is in short pieces), STR becomes ineffective when applied to prenatal paternity testing that uses fetal DNA in maternal blood. In contrast, we analyze each sample using a microarray with >300Kindividual genetic markers called SNPs. By analyzing this many SNPs we are able to create an accurate geneticblueprint of the sample which is then used to identify or exclude paternity. Q. Can testing can be performed on twins or multiple gestation pregnancies? A. No, testing cannot be performed on a mother that is pregnant with twins or multiple fetuses. |
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